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日期:2024-08-10
The M1 and M2 paradigm of macrophage activation: time for reassessment Fernando O. Martinez 1 and Siamon Gordon 2 1. Botnar Research Center, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill ......
Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptoc
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日期:2024-08-09
Cryptococcus neoformans induces only weak macrophage polarization. We next evaluated the direct effect of C. neoformans on in vitro M1/M2 macrophage polarization. For these studies, RAW 264.7 macrophages were incubated for 24 h with nonimmune mouse ......
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日期:2024-08-08
Macrophage polarization is increasingly recognised as an important pathogenetic factor in inflammatory and neoplastic diseases. Proinflammatory M1 macrophages promote T helper (Th) 1 responses and show tumoricidal activity. M2 macrophages contribute to .....
JCI - An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing
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日期:2024-08-09
Macrophages mount a distinct activation phenotype in CVUs. We hypothesized that macrophages from CVUs fail to switch from proinflammatory M1 macrophages to the antiinflammatory M2 macrophages required for tissue remodeling and restoration. We studied ......
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日期:2024-08-12
Nucleofection in Rat Kupffer Cells Freshly isolated Kupffer cells were transfected using the Amaxa mouse macrophage Nucleofector kit according to the instructions of the manufacturer using the Y-001 program (Lonza, Cologne, Germany), except for the follow...
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日期:2024-08-05
4 Application Note Differentiation of M1 or M2Macrophages from PBMC/Monocytes Use aseptic techniques and a laminar fiow bench. Macrophage Differentiation A) Media and solutions Monocyte Attachment Medium (C-28051) M1- or M2-Macrophage Generation ......
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infecti
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日期:2024-08-06
Macrophages can be divided into two subsets, M1 and M2, which have crucial differences in their function. Akira and colleagues identify the histone demethylase Jmjd3 as a key ......
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日期:2024-08-12
RESULTS M1 macrophage markers were increased by high-fat feeding and decreased by pioglitazone treatment, while M2 macrophage markers were not. Before testing the effects of high-fat treatment or pioglitazone treatment on ATMs ......