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Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in A
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日期:2024-07-29
Tien-Hsien Liquid (THL) is a Chinese herbal mixture that has been used worldwide as complementary treatment for cancer patients in the past decade. Recently, THL has been shown to induce apoptosis in various types of solid tumor cells in vitro. However, t...
Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid A
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日期:2024-07-24
Cell Lines W2671T and W2830T cell lines were generated from APC − /PTEN − murine ovarian tumors. Briefly, fresh ovarian tumor tissues were mechanically minced with sterile scalpels and further digested at 37 C with 0.05% Trypsin-EDTA for 20 minutes. Cells...
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日期:2024-07-25
Applications Key: W=Western Blotting IHC-P=Immunohistochemistry (Paraffin) IHC-F=Immunohistochemistry (Frozen) IF-IC=Immunofluorescence (Immunocytochemistry) F=Flow Cytometry Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey Pg=Pig...
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日期:2024-07-23
Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene.[1] Multiple transcript variants encoding different i...
Cell Death and Disease - Protein tyrosine phosphatase 1B modulates GSK3[beta]/Nrf2 and IGFIR signali
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日期:2024-07-22
Brought to you by the editorial team of Cell Death and Differentiation, Cell Death and Disease is a peer-reviewed author-pays online journal in the field of translational cell death. It seeks to promote diverse and integrated areas of Experimental and Int...
Molecular Cancer | Full text | Combined targeting of mTOR and c-MET signaling pathways for effective
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日期:2024-07-25
The AKT/mTOR pathway is constitutively hyperactivated in EpS To investigate whether the AKT/mTOR pathway was activated in EpS, we examined the expression of its related molecules in Asra-EPS and VAESBJ cells. AKT, mTOR, and S6 ribosomal ......
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日期:2024-07-27
Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate the brain die of unknown causes. Here, we identify plasmin from the ... Introduction Metastasis is the main cause of death from cancer, but biologically, metastas...
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日期:2024-07-27
Oncogene is one of the world’s leading cancer journals. It is published weekly and covers all aspects of the structure and function of Oncogenes. ... Top of page Results Human breast cancers and their metastases retain active BMP signaling BMP ligands are...