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日期:2024-09-14
Stem cells represent natural units of embryonic development and tissue regeneration. Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity and developmental potential to differentiate into virtually any cell type of an...
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日期:2024-09-08
Motor neurons are cells located in specific areas of the central nervous system, such as brain cortex (upper motor neurons), brain stem, and spinal cord (lower motor neurons), which maintain control over voluntary actions. Motor neurons are affected prima...
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日期:2024-09-11
2. The Embryonic Stem Cell As stated in the first chapter, an embryonic stem cell (ES cell) is defined by its origin. It is derived from the blastocyst stage of the embryo. The blastocyst is the stage of embryonic development prior to implantation in the ...
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日期:2024-09-12
II. Human Embryonic Stem Cells: Sources, Maintenance, and Common Properties Human embryonic stem cells (hESCs) are pluripotent stem cells derived from various stages of embryonic development. hESCs are uniquely capable ......
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model : Arti
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日期:2024-09-08
Abstract Here we report an in vitro model system for studying the molecular and cellular mechanisms that underlie the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Embryonic stem cells (ESCs) derived from mice carrying normal or mutant .....
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日期:2024-09-08
Differentiation of ES cells in culture When removed from the factors that maintain them as stem cells, ES cells will differentiate and, under appropriate conditions, generate progeny consisting of derivatives of the three embryonic germ layers ......
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日期:2024-09-14
We have analysed the surface antigen phenotype of a human embryonic stem (hES) cell line (H7) and the changes that occur upon differentiation induced by retinoic acid, hexamethylene bisacetamide and dimethylsulphoxide. The undifferentiated stem cells ......
Neuronal Properties, In Vivo Effects, and Pathology of a Huntington's Disease Patient-Derived Induce
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日期:2024-09-14
Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can be used to model different human diseases. They may also serve as sources of transplantable cells that can be used in novel cell therapies. Here, we analyzed neuronal prop...