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日期:2024-07-13
The primary function of adult (somatic) stem cells is to maintain tissue homeostasis by replenishing senescent or damaged cells. For example, normal repair and ......
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日期:2024-07-12
Abstract Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how immune cells impact on these stem cells within their niche is not well understood. Here...
JCI - Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-
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日期:2024-07-10
KRT15 expression levels correlate with epithelial stem cell characteristics of small cell size and cell cycle quiescence. To evaluate changes in hair follicle stem cell numbers in human scalp, we used KRT15 expression as a stem cell marker. We focused on ...
Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches
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日期:2024-07-11
(a) Schematic representation of the methods used for the generation and transplantation of a bioengineered hair follicle germ. (b) Phase-contrast images of murine embryonic back skin, tissues, dissociated single cells and bioengineered hair follicle germ,...
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日期:2024-07-12
Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Fuchs and colleagues use a genome-wide survey to discover that Wnt effectors TCF3, TCF4 and Groucho (TLE) coordinately repress Wnt target genes. They find that although [beta ...
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日期:2024-07-10
A team 'forced' induced pluripotent stem cells to make large quantities of epithelial stem cells and implanted them into mice, regenerating human skin cells and hair follicles. ... 'Fewer allergies among children in dishwasher-free homes' Sunlight continu...
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日期:2024-07-11
1. Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Bo...
First Study to Convert Adult Human Cells to Hair-Follicle-Generating Stem Cells has Implications for
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日期:2024-07-09
Hair shafts (arrowheads) formed by induced pluripotent stem cell-derived epithelial stem cells compared to mouse hair (arrows). Credit: Ruifeng Yang, Perelman School of Medicine, University of Pennsylvania Related Links Perelman School of Medicine at the ...