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日期:2024-07-08
Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. It is a medical procedure in the ......
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日期:2024-07-09
Definitive hematopoietic stem cell pools emerge from intra- (AGM) and extra- (yolk sac and placenta) embryonic hematopoietic sites. When the circulation is established and functional, HSCs start their migratory journey and colonize the placenta, followed...
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日期:2024-07-06
Hematopoietic stem cell transplantation (HSCT) involves the intravenous (IV) infusion of autologous or allogeneic stem cells to reestablish hematopoietic function in patients whose bone marrow or immune system is damaged or defective. Essential update: Ne...
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日期:2024-07-09
This article describes a protocol used to study the homing of hematopoietic cells to their niches in the bone marrow. ... Homing is the process whereby bone marrow cells including stem cells, progenitor cells and differentiated cells, their way into the b...
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日期:2024-07-11
Hematopoiesis in the embryo The embryo is thought to provide specific conditions for the emergence and expansion of HSC. The yolk sac was initially believed to be the unique organ generating HSC that can colonize the embryo, as no other embryonic tissue h...
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日期:2024-07-05
Thesemobilizershaverecentlybeenusedinnon-hema-tological clinical trials to stimulate post-injury healing processes. For example, in a trial of post acute myocar-dial infarct patients, administration of G-CSF for 5 days resulted in significant inhibition o...
Laboratory Investigation - Melanoma stem cells and metastasis: mimicking hematopoietic cell traffick
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日期:2024-07-11
Despite the accumulating body of evidence in support of the CSC theory, there is significant controversy surrounding certain aspects. One topic of debate arises from confusion regarding the definition of CSCs and their relationship to physiological stem c...
Hematopoietic stem cell niche maintenance during homeostasis and regeneration : Nature Medicine : Na
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日期:2024-07-07
The maintenance and proliferation of hematopoietic stem cells after injury is regulated by signals from the bone marrow stem cell niche. ... Quiescent HSCs localize to small arterioles of the endosteal region, which are ensheathed by NG2 + nestin bright p...