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日期:2024-08-12
Immortal time bias can arise when the period between cohort entry and date of first exposure, e.g., to a drug, during which death has not occurred, is either ......
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日期:2024-08-13
2007年12月3日 - In a previous paper, I identified 20 observational studies of the effects of commonly prescribed drugs that were subject to immortal time bias ......
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日期:2024-08-17
These cohort studies used a flawed approach to design and data analysis which can lead to immortal time bias. We describe the bias from 20 of these studies ......
Antivirals for Treatment of Influenza: A Systematic Review and Meta-analysis of Observational Studie
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日期:2024-08-16
Background: Systematic reviews of randomized, controlled trials in patients with influenza suggest a lack of evidence about the effects of antiviral therapy on several patient-important outcomes of influenza. Purpose: To systematically review observationa...
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日期:2024-08-16
Objective Several meta-analyses of observational studies suggested that metformin use reduces cancer risk in type 2 diabetes. However, this result was not confirmed by the few available randomized controlled trials (RCTs), and many observational studies o...
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日期:2024-08-12
Attrition Bias Update—Here's our current thinking as of 02/13/2013: Significant attrition, whether it be due to loss of patients or discontinuation or some other reason, is a reality of many clinical trials. And, of course, the key question in any study i...
Specialist Cohort Event Monitoring Studies: A New Study Method for Risk Management in Pharmacovigila
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日期:2024-08-16
Title Specialist Cohort Event Monitoring Studies: A New Study Method for Risk Management in Pharmacovigilance Open Access Available under Open Access This content is freely available online to anyone, anywhere at any time. Journal Drug Safety Volume 38, I...
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日期:2024-08-13
The test-negative design has emerged in recent years as the preferred method for estimating influenza vaccine effectiveness (VE) in observational studies. Howev ... 1. Introduction Annual estimates of influenza vaccine effectiveness (VE) are needed to mon...