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日期:2024-09-21
1. Annu Rev Neurosci. 2004;27:509-47. The synaptic vesicle cycle. Sudhof TC. Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release, synapt...
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日期:2024-09-20
The synaptic vesicle cycle Synapses can fire at very rapid rates. Synapses also need to fire reliably and they are often located far away from the soma where most protein synthesis occurs. Perhaps as one mechanism to enable the synapse to function under t...
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日期:2024-09-20
1. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9861-6. Epub 2004 Jun 21. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Lynch BA(1), Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B. ....
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日期:2024-09-27
A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the molecular life sciences ... Figure 1. Pathways of synaptic vesicle recycling and examples of methods to monitor synaptic vesicle endocyt...
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日期:2024-09-26
3 Roles of SNARE Proteins in Synaptic Vesicle Fusion 39 Fig. 3.1 Molecular description of the SNAREs. By assembling into a four-helix parallel bundle, the SNAREs bridge the gap between the two membranes destined to fuse. (a) In the case of the neuronal .....
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日期:2024-09-22
Some vesicles are made when part of the membrane pinches off the endoplasmic reticulum or the Golgi complex. Others are made when an object outside of the cell is surrounded by the cell membrane. Capturing cargo molecules[edit] The assembly of vesicles re...
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日期:2024-09-27
In exocytosis, the membrane of the vesicle fuses with the membrane of the synaptic terminal. Without a compensatory mechanism, the pre-synaptic membrane would enlarge as vesicular membrane would continuously be added to the plasma membrane. This ......
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日期:2024-09-25
Abstract Synaptic vesicle recycling has long served as a model for the general mechanisms of cellular trafficking. We used an integrative approach, combining quantitative immunoblotting and mass spectrometry to determine protein numbers ......