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The Promise of Induced Pluripotent Stem Cells (iPSCs) Charles A. Goldthwaite, Jr., Ph.D. In 2006, ......
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Potency specifies the differentiation potential (the potential to differentiate into different cell ......
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Mouse ES (a) and iPS (b) cells form dome-shaped, refractile colonies. These colonies are in contrast to the flat morphology of mouse epiblast-derived stem cells (f), which resemble human ES (d) and iPS (e) cells. Human iPS cells induced into a naive pluri...
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The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluripotent stem cells (iPSCs) differs from that of...
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iPS-cell technology is a novel method for generating pluripotent stem cells 10, 11, 12. The method is striking in that it can convert somatic cells directly into pluripotent cells, in a manner that is totally independent of the availability of embryonic c...
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Figure 1. Human induced pluripotent stem cells can be differentiated into cell types to study neurological disorders. Human induced pluripotent (iPS) stem cells can be differentiated into cell types relevant for the study of neurological disorders....
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1. Stem Cells. 2011 Sep;29(9):1362-70. doi: 10.1002/stem.685. Crucial role of c-Myc in the generation of induced pluripotent stem cells. Araki R, Hoki Y, Uda M, Nakamura M, Jincho Y, Tamura C, Sunayama M, Ando S, Sugiura M, Yoshida MA, Kasama Y, Abe M. .....
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1. J Anat. 2012 Feb;220(2):122-30. doi: 10.1111/j.1469-7580.2011.01459.x. Epub 2011 Dec 2. Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality? Thomson SR, Wishart TM, Patani R, Chandran S, Gillingwate...